Senescence represses the nuclear localization of the serum response factor and differentiation regulates its nuclear localization with lineage specificity
نویسندگان
چکیده
منابع مشابه
Senescence represses the nuclear localization of the serum response factor and differentiation regulates its nuclear localization with lineage specificity.
The differentiation of cultured 3T3T mesenchymal stem cells into adipocytes represses growth factor responsiveness by limiting the nuclear localization of the serum response factor (SRF) that binds to and activates the promoters of growth control genes that contain the serum response elements (SRE), such as junB and c-fos. The regulation of SRF nuclear localization by adipocyte differentiation ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2001
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.114.5.1011